Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca2+-stimulated ATPase (SERCA), with IC50 values ranging from 5 µM to 50 µM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity[1][2][3][4][5][6].
Molecular Weight:
435.56
Purity:
99.91
CAS Number:
[57186-25-1]
Formula:
C27H33NO4
Target:
Calcium Channel,Potassium Channel,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Natural Products
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