KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an Ki value of 0.23 µM, it also inhibits PKA and PKC with Ki values of 10 µM and 4 µM, respectively. KT5823 is a Staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation[1][2][3][4][5].
Molecular Weight:
495.53
Purity:
99.90
CAS Number:
[126643-37-6]
Formula:
C29H25N3O5
Target:
Antibiotic,Apoptosis,Bacterial,PKA,PKC
Application Notes:
MCE Product type: Reference compound
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