Calenduloside E is a pentacyclic triterpenoid saponin that can be extracted from the bark and roots of Aralia ovata, and has anti-inflammatory and anti-apoptotic activities. Calenduloside E alleviates atherosclerosis by regulating macrophage polarization, improves mitochondrial function by regulating the AMPK-SIRT3 pathway, and alleviates acute liver injury. In addition, Calenduloside E promotes the interaction between L-type calcium channels and Bcl-2 related apoptosis genes, inhibits calcium overload, and alleviates myocardial ischemia/reperfusion injury. Calenduloside E also improves non-alcoholic fatty liver disease by regulating heat shock-dependent pathways, and inhibits ROS mediated JAK1-STAT3 pathways to reduce cellular inflammatory responses[1][2][3][4][5][6].
Molecular Weight:
632.82
Purity:
99.07
CAS Number:
[26020-14-4]
Formula:
C36H56O9
Target:
AMPK,Apoptosis,Bcl-2 Family,Calcium Channel,Interleukin Related,JAK,PPAR,Pyroptosis,Reactive Oxygen Species (ROS),SOD,STAT,TNF Receptor
Application Notes:
MCE Product type: Natural Products
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