Groenlandicine, a protoberberine alkaloid, is a cholinesterase inhibitor (AChE (IC50 = 0.54 µM), BChE (IC50 = 3.32 µM)). Groenlandicine non-competitively inhibits BACE1 (IC50 = 19.68 µM, Ki = 21.2) and inhibits RLAR (IC50 = 140.1 µM), HRAR (IC50 = 154.2 µM), and total ROS generation (IC50 = 51.78 µM) in vitro. Groenlandicine suppresses osteosarcoma cell proliferation while promoting apoptosis. Groenlandicine inhibits the tumor growth when combined with Cisplatin (HY-17394). Groenlandicine can be used for the study on osteosarcoma, Alzheimers disease and diabetes mellitus [1][2][3][4][5].
Molecular Weight:
322.34
Purity:
99.87
CAS Number:
[38691-95-1]
Formula:
C19H16NO4+
Target:
Apoptosis,Beta-secretase,Cholinesterase (ChE),Reactive Oxygen Species (ROS),Topoisomerase
Application Notes:
Natural Products
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