Garcinone D is an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways, and an inhibitor of CDK2/CyclinE1 (IC50 for CDK2/CyclinE1 is 28.23 µM). Garcinone D promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression and enhancing the Nrf2/HO-1 signaling pathway. In addition, Garcinone D blocks the tumor cell cycle by inhibiting CDK2/CyclinE1. Garcinone D can promote the proliferation of C17.2 neural stem cells and inhibit prostate and breast cancer[1][2].
Molecular Weight:
428.47
Purity:
99.30
CAS Number:
[107390-08-9]
Formula:
C24H28O7
Target:
Keap1-Nrf2,Reactive Oxygen Species (ROS),STAT
Application Notes:
MCE Product type: Natural Products
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