Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time- and dose-dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active[1][2].
Molecular Weight:
414.45
Purity:
99.51
CAS Number:
[76996-27-5]
Formula:
C23H26O7
Target:
ATM/ATR,CDK,Hedgehog,STAT
Application Notes:
MCE Product type: Natural Products
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