Phytohemagglutinin (PHA-M), the major seed lectin of the common bean, Phaseolus vulgaris, is a T-cell activator. Phytohemagglutinin stimulates human mononuclear leukocytes, inducing the expression of ChAT mRNA and potentiating ACh synthesis. Phytohemagglutinin induces dose- and time-dependent toxicity in THP-1 monocytes/macrophages, alters cellular morphology, causes organelle dysfunction, and increases the expression of NF-kappaB, COX2, IL-1beta[1][2][3][4].
Purity:
80.00
CAS Number:
[9008-97-3]
Target:
COX,Interleukin Related,NF-kappaB,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Natural Products
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