Hibifolin is a flavonol glycoside that can be isolated from Helicteres isora. Hibifolin is an inhibitor of adenosine deaminase (ADA) (Ki = 49.92 µM). Hibifolin protects neurons against beta-amyloid-induced neurotoxicity. Hibifolin possesses a potent protective activity against cell death induced by aggregated Abeta. Hibifolin can abolish Abeta-induced caspase-3 and caspase-7 activation. Hibifolin induces Akt phosphorylation in cortical neurons. Hibifolin is also a natural sortase A (SrtA) inhibitor (IC50 = 31.2 µM) through direct binding to SrtA protein. Hibifolin attenuates the pathogenic behavior of Staphylococcus aureus including adhesion, invasion, and biofilm formation. Hibifolin improves the survival of pneumonia induced by Staphylococcus aureus in mouse model and alleviates pathological damage. Hibifolin shows a synergistic antibacterial effect with Cefotaxime (HY-A0088A)[1][2][3].
Molecular Weight:
494.36
Purity:
99.70
CAS Number:
[55366-56-8]
Formula:
C21H18O14
Target:
Adenosine Deaminase,Bacterial,Caspase
Application Notes:
MCE Product type: Natural Products
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