Isotoosendanin is an orally active TGFbetaR1 inhibitor and abrogating its kinase activity (IC50 = 6732 nM). Isotoosendanin inhibits the JAK/STAT3 signaling pathway by directly targeting SHP-2, enhancing its stability, and reducing its ubiquitination. Isotoosendanin inhibits TGF-beta-induced reduces the migration, invasion, and metastasis in triple-negative breast cancer (TNBC) cells. Isotoosendanin exhibits anti-tumor efficacy in TNBC xenograft models and A549 xenograft tumors. Isotoosendanin exhibits significant anti-inflammatory effects in acetic acid-induced vascular permeability and lambda-carrageenan-induced hind paw edema tests. Isotoosendanin can be used for the study of non-small cell lung cancer (NSCLC), TNBC and inflammation[1][2][3].
Molecular Weight:
574.62
Purity:
99.51
CAS Number:
[97871-44-8]
Formula:
C30H38O11
Target:
Apoptosis,JAK,STAT,TGF-beta Receptor
Application Notes:
MCE Product type: Natural Products
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