Steffimycin B is an anthracycline bacterial metabolite originally isolated from Streptomyces. It binds to DNA, preferentially intercalating at sites containing cytosine and guanine.2 Steffimycin B is cytotoxic to MCF-7, KB, NCI-H187, and Vero cells (IC50s=3.5, 6.75, 3.28, and 10.5 µM, respectively). It is active against M. tuberculosis (MIC=5.2 nM), B. cereus (MIC=1.56 µg/mL), and P. falciparum (IC50=2.19 µM).
Molecular Weight:
588.56
CAS Number:
[54526-94-2]
Formula:
C29H32O13
Target:
Bacterial
Application Notes:
MCE Product type: Natural Products
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