HCGRP-(8-37) is a fragment of human calcitonin gene-related peptide (hCGRP) and an antagonist of the CGRP receptor, with an IC50 of 32.1 pM against the CGRP receptor. HCGRP-(8-37) blocks adenylate cyclase activation induced by CGRP receptor ligands and attenuates vascular responses triggered by CGRP. HCGRP-(8-37) reduces capsaicin-induced vasodilation in porcine nasal mucosa and superficial skin. HCGRP-(8-37) serves as a research tool to distinguish effects mediated by CGRP or calcitonin receptors, and to investigate CGRP-induced vascular effects[1][2].
Molecular Weight:
3125.59
Purity:
99.51
CAS Number:
[119911-68-1]
Formula:
C139H230N44O38
Target:
CGRP Receptor
Application Notes:
MCE Product type: Peptides
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