Vmm-p15 is a peptide agonist optimized for the adhesion G protein-coupled receptor GPR64 (also known as ADGRG2 or HE6). The affinity of VPM-p15 with GPR64 is significantly higher than that of the original p15 peptide. The cAMP level induced by VMM-P15 increased significantly, activated GPR64, and triggered downstream Gs, Gq, and G12/13 signaling. VPM-p15 can be used to study the activation mechanism of adherent GPCR family members[1].
Molecular Weight:
1631.91
Purity:
98.25
Formula:
C75H126N18O22
Target:
Adhesion G Protein-coupled Receptors (AGPCRs)
Application Notes:
MCE Product type: Peptides
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