cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 of 19 µM (in U2OS) and 16 µM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1alpha, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers[1].
Molecular Weight:
738.94
Purity:
99.37
CAS Number:
[1446322-73-1]
Formula:
C38H54N6O7S
Target:
HIF/HIF Prolyl-Hydroxylase,VEGFR
Application Notes:
Peptides
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