TAT-PiET-PROTAC is a proteolysis-targeting chimera (PROTAC)-modified TAT-PiET (HY-P10445), which is a cell-penetrating peptide targeting the extra-terminal (ET) domain of BRD4. TAT-PiET-PROTAC can reduce BRD4 and JMJD6 levels and inhibit cell proliferation. TAT-PiET-PROTAC also resists the endocrine resistance of ERalpha-positive breast cancer cells. TAT-PiET-PROTAC can be used for the research of cancer, such as breast cancer[1].
Molecular Weight:
3430.01
Purity:
98.04
CAS Number:
[3036046-04-2]
Formula:
C151H250N54O36S
Target:
Epigenetic Reader Domain,PROTACs
Application Notes:
MCE Product type: Peptides
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