Corza6 TFA is a potent and selective human voltage-gated proton channel (hHv1) peptide inhibitor. Corza6 TFA binds to the external voltage sensor domain (VSD) loop in hHv1 with a Kd of ~1 nM at the natural, hyperpolarized resting membrane potential (RMP) of mammalian cells. Corza6 TFA allows capacitation in sperm and permits sustained reactive oxygen species (ROS) production in white blood cells (WBCs)[1].
Molecular Weight:
4704.29 (free base)
Purity:
95.53
Formula:
C203H293N55O61S7.xC2HF3O2
Target:
Proton Pump,Reactive Oxygen Species (ROS)
Application Notes:
Peptides
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