PIC1 PA, a 15 amino-acid peptide, is a potent PIC1 analog that inhibits classical pathway mediated complement activation. PIC1 PA functionally disrupts the C1s-C1r-C1r-C1s/MASPs interaction with collagen-like region (CLR) of C1q/MBL, respectively. PIC1 PA specifically binds to the CLR of C1q and bounds to purified C1q with a mean equilibrium dissociation constant (KD) of 33.3 nM[1].
Molecular Weight:
1642.98
Purity:
98.37
CAS Number:
[1356469-36-7]
Formula:
C71H123N19O21S2
Target:
Complement System
Application Notes:
Peptides
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