CPI1 is a multidrug resistance protein 1 (MRP1) inhibitor with a Ki value of 100 nM. CPI1 binds to the same substrate-binding site as leukotriene C4, stabilizes MRP1 in an apo-like inward-facing conformation, blocks the conformational changes required for ATP hydrolysis and substrate transport, and inhibits the ATPase activity of human and bovine MRP1. CPI1 serves as a tool for investigating the substrate transport mechanism of MRP1. CPI1 is applicable to research related to cancer multidrug resistance[1].
Molecular Weight:
2299.43
Purity:
99.30
CAS Number:
[3085809-95-3]
Formula:
C111H131N23O30S
Target:
P-glycoprotein
Application Notes:
MCE Product type: Peptides
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