ETTAC-2 is a LRG1 PROTAC degrader, degrading LRG1 via the ubiquitin-proteasome pathway with a DC50 value of 8.38 µM. ETTAC-2 penetrates damaged renal cells to reduce the extracellular secretion of LRG1. ETTAC-2 effectively inhibits the TGF-beta-Smad3 signaling pathway and diminishes the secretion of fibrosis-associated extracellular matrix proteins. ETTAC-2 degrades LRG1 within fibrotic kidneys and the efficacy in inhibiting the TGF-beta-Smad3 pathway both in vitro and vivo. ETTAC-2 can be used for renal fibrosis research[1].
Molecular Weight:
1891.07
Purity:
99.94
Formula:
C83H123N23O26S
Target:
PROTACs,TGF-beta/Smad
Application Notes:
MCE Product type: Peptides
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