ETTAC-2 is a LRG1 PROTAC degrader. ETTAC-2 promotes ubiquitination and degradation of LRG1 (DC50 of 8.38 µM). ETTAC-2 inhibits the TGF-beta-Smad3 signaling pathway and diminishes the secretion of fibrosis-associated proteins. ETTAC-2 attenuates the progression of renal fibrosis[1].
Molecular Weight:
1891.07
Purity:
98.22
Formula:
C83H123N23O26S
Target:
PROTACs,TGF-beta/Smad
Application Notes:
Peptides
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