Tat-IKIP (46-60) is a IkappaB kinase (IKK)-targeting membrane-penetrating peptide. Tat-IKIP (46-60) inhibits IKK activation and NF-kappaB targeted gene expression by disrupting the IKKbeta/NEMO complex. Tat-IKIP (46-60) significantly reduces DSS (HY-116282)-induced acute inflammation in inflammatory bowel disease (IBD) mice model and attenuates Zymosan-induced acute arthritis in acute arthritis model (AAM). Tat-IKIP (46-60) can be used for inflammatory diseases research, such as IBD, pancreatitis and rheumatoid arthritis[1][2].
Molecular Weight:
3189.87
Formula:
C145H246N48O31S
Target:
IKK,NF-kappaB
Application Notes:
MCE Product type: Peptides
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