Nef-M1 (Nef-Motif-1) is an antagonist peptide targeting CXCR4 and an apoptosis inducer derived from a myristoylated protein encoded by the nef gene in HIV. Nef-M1 inhibits tumor angiogenesis and epithelial-mesenchymal transition (EMT). Nef-M1 activates the apoptosis pathway by increasing the level of caspase-3 in cancer cells. Nef-M1 simultaneously inhibits VEGF-A, p-GSK-3beta and vimentin, and enhances E-cadherin, thereby inhibiting angiogenesis and EMT processes. Nef-M1 can be used in the study of colorectal cancer and breast cancer[1][2].
Molecular Weight:
1177.29
CAS Number:
[860401-80-5]
Formula:
C50H76N14O17S
Target:
Apoptosis,Cadherin,Caspase,CXCR,GSK-3,VEGFR
Application Notes:
Peptides
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