LNSMGQD is a peptide that targets the adhesion interface of desmoglein DSG1 and DSG3, and interferes with the DSG trans-interaction single peptide (SP) component. LNSMGQD blocks autoantibody-induced loss of DSG trans-interactions by binding to DSGs, inhibiting p38 MAPK activation and keratin filament retraction. LNSMGQD can be used to study autoimmune skin diseases such as pemphigus vulgaris[1].
Molecular Weight:
763.82
Purity:
99.92
CAS Number:
[1152066-26-6]
Formula:
C29H49N9O13S
Target:
p38 MAPK
Application Notes:
Peptides
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