Astressin 2B TFA is a highly selective CRFR2 antagonist that does not cross the blood-brain barrier. Astressin 2B TFA blocks the CRFR2-mediated protective effects, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats and reversing the protective effects of urocortin I on intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. In the C. difficile toxin A-mediated enteritis model, Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice, significantly aggravating intestinal epithelial damage, edema, neutrophil migration and the expression of various proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2[1][2][3].
Molecular Weight:
4041.69 (free base)
Purity:
99.54
Formula:
C183H307N49O53.xC2HF3O2
Target:
CRFR
Application Notes:
MCE Product type: Peptides
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