RP-182 is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (Kd = 8 µM) on the surface of tumor-associated macrophages (TAMs). RP-182 induces a conformational switch of the CD206 receptor, which activates NF-kappaB signaling and phagocytosis in CD206high TAMs. RP-182 has dual function: activation of canonical NF-kappaB signaling, triggering TNFalpha secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 is used in pancreatic cancer and melanoma research[1][2].
Molecular Weight:
1374.68
CAS Number:
[1895883-60-9]
Formula:
C69H103N19O11
Target:
Apoptosis,Caspase,NF-kappaB,TNF Receptor
Application Notes:
Peptides
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