HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-alpha and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects[1].
Molecular Weight:
2241.85
Formula:
C111H185N31O18
Target:
Bacterial,ERK,Interleukin Related,JNK,NO Synthase,p38 MAPK,Reactive Oxygen Species (ROS),Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Peptides
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