TC4 is a highly balanced single-molecule quadruple agonist that can respectively activate GIPR, GLP-1R, GcgR, and Y2R with IC50 values of 0.95, 31, 81, and 1100 nM respectively. TC4 exhibits extremely strong signal bias on GLP-1R and has very low recruitment efficacy for beta-inhibitor protein 2 (betaArr2) and this strong cAMP preference is believed to maximize metabolic benefits (such as weight loss and hypoglycemia) while possibly minimizing side effects mediated by beta-inhibitor protein recruitment (such as receptor desensitization). TC4 can be used for research on obesity and diabetes[1].
Molecular Weight:
5967.74
Formula:
C277H423N69O78
Target:
GCGR,GLP Receptor,Neuropeptide Y Receptor
Application Notes:
MCE Product type: Peptides
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