TC2 is an efficient GIPR-preferring monomeric quadruple agonist that can respectively activate GIPR, GLP-1R, GcgR, and Y2R with IC50 values of 0.47, 2.1, 30, and 55 nM respectively. TC2 exhibits a significant GLP-1R preference, with a significant reduction in beta-inhibitory protein 2 (betaArr2) recruitment, while maintaining a strong cAMP signal. TC2 can be used for research on obesity and diabetes[1].
Molecular Weight:
5659.45
Formula:
C263H407N67O72
Target:
GCGR,GLP Receptor,Neuropeptide Y Receptor
Application Notes:
MCE Product type: Peptides
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