M871 (Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide) is an orally active and selective galanin receptor type 2 (GalR2) antagonist. M871 exhibits Ki values of 13.1 nM, 420 nM and >10 µM for GalR2, GalR1 and GalR3 respectively. M871 relieves the mice allergic rhinitis by reducing IgE production, as well as the number of B cells in tissues. M871 can inhibit the nerve invasion of salivary adenoid cystic carcinoma (SACC) and alleviate myocardial ischemia-reperfusion injury. M871 can be used for research on GalR2-related diseases (such as epilepsy, pain)[1][2][3][4][5][6][7].
Molecular Weight:
2287.61
Purity:
99.98
CAS Number:
[908844-75-7]
Formula:
C108H163N27O28
Target:
Neuropeptide Y Receptor
Application Notes:
MCE Product type: Peptides
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