Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial[1][2].
Molecular Weight:
1161.44
Purity:
99.25
CAS Number:
[1507930-57-5]
Formula:
C55H96N14O13
Target:
Connexin,Gap Junction Protein
Application Notes:
MCE Product type: Peptides
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