Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial[1][2].
Molecular Weight:
1275.46
Purity:
99.97
Formula:
C57H97F3N14O15
Target:
Connexin,Gap Junction Protein
Application Notes:
MCE Product type: Peptides
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