Gy-CATH is an anionic antimicrobial peptide. Gy-CATH activates MAPK and NF-kappaB signaling pathways (elevated levels of phospho-ERK, -p38, -JNK, -p65, and -IkappaBalpha). Gy-CATH upregulates the expression levels of three physiological anticoagulant pathways. Gy-CATH inhibits ADP-, Collagen-, and PMA-induced platelet aggregation. Gy-CATH has no direct antimicrobial activity, but shows significant preventive abilities against mice infected with Staphylococcus aureus, Escherichia coli, and Methicillin (HY-121544)-resistant Staphylococcus aureus. Gy-CATH exhibits potent immunomodulatory activity, enhancing macrophage-and neutrophil-mediated bactericidal functions. Gy-CATH significantly reduces the extent of pulmonary fibrin deposition and prevents thrombosis in mice[1][2].
Molecular Weight:
2701.03
Formula:
C118H186N28O40S2
Target:
Bacterial,JNK,NF-kappaB,p38 MAPK,PERK
Application Notes:
MCE Product type: Peptides
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