Cyclomarin monomer-2 (Compound 10), a cyclomarin monomer, is a pre-dimerization precursor that can form Homo-BacPROTACs targeting the degradation of ClpC1. Cyclomarin monomer-2 binds to the Mtb ClpC1 protein with a KD of 4.0 nM. The MIC of Cyclomarin monomer-2 against the Mtb H37Rv standard strain is 3.1 µM. Cyclomarin monomer-2 can be used as a key intermediate in the development of Homo-BacPROTACs[1].
Molecular Weight:
913.11
Formula:
C49H68N8O9
Target:
Bacterial,Drug Intermediate
Application Notes:
MCE Product type: Peptides
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