COG112 is an antennapedia-linked apoE-mimetic peptide. COG112 attenuates induction of NO production, inhibits CXC chemokines KC and MIP-2. COG112 reduces nuclear translocation of NF-kappaB. COG112 inhibits phosphorylation of IkappaB-alpha and prevents the degradation of IkappaB-alpha. COG112 inhibits the inflammatory response to Citrobacter rodentium [1].
Molecular Weight:
4501.57
CAS Number:
[1314623-74-9]
Formula:
C204H352N72O39S2
Target:
Apolipoprotein,CXCR,IKK,NF-kappaB,NO Synthase
Application Notes:
MCE Product type: Peptides
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