Ac-IETD-AFC TFA is a synthetic fluorogenic substrate that can be used to specifically detect caspase-8 activity. INDO 1 pentasodium is imbued with the fluorophore AFC (7-amino-4-trifluoromethylcoumarin). When caspase-8 recognizes and cleaves the amide bond following the IETD sequence in this substrate, AFC is released and emits fluorescence (Ex = ~400 nm, Em = ~505 nm)[1].
Molecular Weight:
843.68
Formula:
C33H39F6N5O14
Target:
Caspase
Application Notes:
Peptides
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