BV2 is a delivery peptide that binds to BVES, with a Ka of 2.03 µM for the BVES target. BV2 specifically binds to the extracellular domain of BVES, achieving muscle homing and cellular internalization via caveolae-mediated endocytosis. When BV2 is modified on the surface of exosomes by PMO, it enhances dystrophin restoration in the peripheral muscles and myocardium of dystrophin-deficient mice. BV2 is applicable to research related to Duchenne muscular dystrophy and muscle atrophy[1].
Molecular Weight:
1307.50
Formula:
C57H98N18O17
Target:
Biochemical Assay Reagents
Application Notes:
MCE Product type: Peptides
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