Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV TFA preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV TFA has analgesic effects on animal models of inflammatory and neuropathic pain[1][2].
Molecular Weight:
4106.78(free base)
Purity:
98.52
Formula:
C174H278N52O51S6.xC2HF3O2
Target:
Sodium Channel
Application Notes:
MCE Product type: Peptides
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