beta-Amyloid (1-42) (Amyloid beta-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimers disease and Downs syndrome. beta-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. beta-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AbetaOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity, on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Abeta42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death[1][1][2][3][4][5][6][7].
Molecular Weight:
4514.04
Purity:
99.89
CAS Number:
[107761-42-2]
Formula:
C203H311N55O60S
Target:
Amyloid-beta
Application Notes:
MCE Product type: Peptides
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