Obtustatin is a non-RGD disintegrin consisting of 41 residues. Obtustatin inhibits the adhesion of alpha1beta1 integrin to type IV Collagen (HY-NP003), blocks alpha1beta1 integrin signaling in endothelial cells, and suppresses FGF2-induced angiogenesis. Obtustatin inhibits tumor progression in mouse models and upregulates VEGF expression in sarcoma-bearing mice. Obtustatin can be used in research related to Lewis lung carcinoma and S-180 sarcoma[1][2][3].
Molecular Weight:
4393.06
Purity:
99.94
CAS Number:
[404882-00-4]
Formula:
C184H284N52O57S8
Target:
Integrin,VEGFR
Application Notes:
MCE Product type: Peptides
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