ADWX 1 is a new peptide inhibitor that is potent and selective for Kv1.3 with an IC50 value of 1.89 pM. ADWX 1 inhibits Kv1.3 channel activity specifically to inhibit both the initial calcium signaling and NF-kappaB activation. ADWX 1 ameliorates the disease in rats of experimental autoimmune encephalomyelitis (EAE) models. ADWX 1 can be used to study T cell-mediated autoimmune diseases[1][2].
Molecular Weight:
4071.85
Formula:
C169H281N57O46S7
Target:
Potassium Channel
Application Notes:
MCE Product type: Peptides
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