Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC50 value of 10 nM. Spadin TFA enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin TFA can be used for antidepressant research[1][2].
Molecular Weight:
2126.36
Purity:
99.73
Formula:
C92H143F3N26O24
Target:
5-HT Receptor,Potassium Channel
Application Notes:
MCE Product type: Peptides
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