Teduglutide (ALX-0600) is an analog of human glucagon like peptide-2 (GLP-2). Teduglutide can activate the expression of nuclear receptor subfamily 4 group a member 1 (NR4a1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis[1][2][3][4].
Molecular Weight:
3752.13
Purity:
99.94
CAS Number:
[197922-42-2]
Formula:
C164H252N44O55S
Target:
FXR,Nuclear Hormone Receptor 4A/NR4A
Application Notes:
MCE Product type: Peptides
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