Teduglutide TFA is a dipeptidyl peptidase IV resistant glucagon-like peptide 2 (GLP-2) analogue. Teduglutide TFA can activate the expression of nuclear receptor subfamily 4 group a member 1 (NR4a1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide TFA can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis[1][2][3][4].
Molecular Weight:
3752.13 (free acid)
Formula:
C164H252N44O55S.xC2HF3O2
Target:
FXR,Nuclear Hormone Receptor 4A/NR4A
Application Notes:
MCE Product type: Peptides
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