alpha-Casein (90-95) is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. alpha-Casein (90-95) inhibits the secretion of beta-hexosaminidase by rat peritoneal mast cells (PMC) with IC50= 0.1 µM. alpha-Casein (90-95) inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC50 of 0.94 nM, 137 nM, and 6.92 nM, respectively. alpha-Casein (90-95) activates Gi-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. alpha-Casein (90-95) can be used in the study of the mechanisms of allergic diseases and prostate cancer[1][2][3].
Molecular Weight:
783.91
Purity:
99.51
CAS Number:
[83471-50-5]
Formula:
C38H57N9O9
Target:
Biochemical Assay Reagents,Opioid Receptor
Application Notes:
MCE Product type: Peptides
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