Proadrenomedullin (1-20), human is a potent hypotensive and catecholamine release-inhibitory peptide released from chromaffin cells. Proadrenomedullin (1-20) inhibits catecholamine secretion in PC12 pheochromocytoma cells (IC50 ~ 350 nM) by suppressing Na+/Ca2+ influx and blocking desensitization. Proadrenomedullin (1-20), human specifically acts on nicotinic cholinergic receptors in a non competitive manner. Proadrenomedullin (1-20), human can be used for research on conditions such as hypertension[1][2].
Molecular Weight:
2460.84
Purity:
99.71
CAS Number:
[150238-87-2]
Formula:
C112H178N36O27
Target:
Calcium Channel,nAChR,Sodium Channel
Application Notes:
MCE Product type: Peptides
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