IT9302 is a synthetic IL-10 agonist with the activity of inducing tolerogenic dendritic cells. IT9302 is able to mimic multiple effects of IL-10, including downregulating the antigen presentation machinery and increasing the sensitivity of tumor cells to natural killer cell-mediated lysis. IT9302 can also hinder the response of human monocytes to differentiation factors and reduce the antigen presentation and co-stimulatory capacity of dendritic cells. Dendritic cells treated with IT9302 showed a weakened ability to stimulate T cell proliferation and interferon-gamma production. IT9302 exerts its effects through mechanisms that are partially different from IL-10, involving STAT3 inactivation and regulation of the NF-kappaB intracellular pathway. IT9302-treated dendritic cells showed enhanced expression of membrane-bound TGF-beta, associated with the effective induction of foxp3+ regulatory T cells[1].
Molecular Weight:
1127.38
Purity:
96.11
CAS Number:
[173959-12-1]
Formula:
C48H82N14O13S2
Target:
Endogenous Metabolite
Application Notes:
MCE Product type: Peptides
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