Dynorphin A (1-8) is a ligand with preference for the kappa-opioid receptor, and its IC50 value against human placental kappa-opioid receptor is 330 nM. Dynorphin A (1-8) mediates neuroprotective effects by inhibiting oxidative stress, suppressing apoptosis, and competitively displacing the binding of kappa partial agonists. Dynorphin A (1-8) is the dominant opioid peptide in human placental villi and tissue extracts, it undergoes rapid hydrolysis and can enter the central nervous system via intranasal administration. Dynorphin A (1-8) can be used in studies related to ischemic stroke[1][2][3].
Molecular Weight:
981.15
Purity:
99.88
CAS Number:
[75790-53-3]
Formula:
C46H72N14O10
Target:
Endogenous Metabolite,Opioid Receptor
Application Notes:
MCE Product type: Peptides
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