MAIT-203, a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 binds APC-ARM with a Ki of 0.015 µM and a Kd of 0.036 µM. MAIT-203 significantly represses the migration and invasion of colorectal cancer cells.
Molecular Weight:
2517.85
Formula:
C106H177N43O29
Target:
Drug Derivative
Application Notes:
MCE Product type: Peptides
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