Tyr-alpha-CGRP (human) TFA is an N-terminally extended human alpha-CGRP analog. Tyr-alpha-CGRP (human) TFA can bind to membrane preparations from rat brain and spleen with IC50 values of 0.2 nM and 0.5 nM, respectively, and induce positive chronotropic and inotropic effects in isolated guinea pig right and left atria with EC50 values of 282 nM and 74 nM, respectively. Tyr-alpha-CGRP (human) TFA also inhibits contractile responses in rat vas deferens with an EC50 value of 1.9 nM[1][2].
Molecular Weight:
3952.48 (free base)
Formula:
C172H276N52O51S2.xC2HF3O2
Target:
CGRP Receptor
Application Notes:
MCE Product type: Reference compound
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