Urocortin III (human) TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) TFA preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) TFA potently binds to type 2 CRF receptors, specifically mCRF2beta (Ki = 13.5 nM) and rCRF2alpha (Ki = 21.7 nM), while demonstrating negligible affinity for hCRF1 (Ki >100 nM). Urocortin III (human) TFA mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion[1][2].
Molecular Weight:
4137.87 (free base)
Purity:
95.1
Formula:
C185H307N53O50S2.xC2HF3O2
Target:
CRFR
Application Notes:
MCE Product type: Peptides
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