ShK toxin blocks voltage-dependent potassium channel (Kv1.3 channel). ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus). ShK toxin competes with dendrotoxin I and alpha-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation[1][2].
Molecular Weight:
4054.80
CAS Number:
[172450-46-3]
Formula:
C169H274N54O48S7
Target:
Potassium Channel
Application Notes:
MCE Product type: Peptides
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