Mazdutide (IBI-362, LY-3305677) TFA is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide TFA binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide TFA is used in studies of obesity and type 2 diabetes (T2D)[1][2][3].
Molecular Weight:
4563.06 (free base)
Purity:
99.67
Formula:
C210H322N46O67.xC2HF3O2
Target:
GCGR,GLP Receptor
Application Notes:
MCE Product type: Peptides
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